|
Drop by Drop (2017)
So there's this story
in medical history, back in the 1840's, about a man who gets hired at a hospital in Vienna and he starts to notice that there are two maternity wards, and in one of the maternity wards, the death rate among moms and their children who were being born is a lot higher than in the other maternity ward. And he's like, okay, let's look at what's different between the two of them. What could be causing such tremendous death rate in one of them? And the only difference that he found was that one of these maternity wards was run by midwives. The other one was run by medical students who were delivering the kids. And he's like okay, what's the difference between those two? And the difference between those two was that the medical students were going and doing autopsies and working with corpses afterwards. So he thought they must be carrying something on their hands from the corpses over to the moms and their children. And he took this idea to the doctors and was like, you know, you guys should maybe like wash off your hands while you're walking between these two areas or before you help deliver a baby. And the doctors responded with no, you're absolutely insane. We could not be responsible for killing our patients. It can't be our fault. At this point, nobody knew what a germ was. This guy's name was Ignaz Semmelweis. He essentially invented the idea of washing your hands, but when he was alive, it was almost impossible for him to get anybody to listen to him. He actually ended up dying in an insane asylum because he just went crazy because nobody listened to such a simple, mundane solution that ended up saving hundreds of thousands of lives. It just seems so boring and simple today, and when I heard this story, it just made me wonder, well, okay, what else is out there? Has this changed? Are there still Ignaz Semmelweises who have these simple solutions? Or is change in the medical world just like the water that's going through their hands and it just moves slowly drop by drop? - Ready? Good job, I got my drop. I often say we need a pink flamingo on the front yard and calling us the last resort because many, many patients have been to so many other places and so many other doctors that they're at their wit's end. Even when I went to medical school, allergies and even severe allergic conditions like asthma were so poorly understood that we were often being taught about allergy and asthma in the chapter of psychosomatic disorders. There was a tendency back in those days to blame allergies and allergic manifestations of diseases on psychiatric disorders. This just shows you how much things have changed over the last 30 years. You can have vaginal irritation, vaginitis from allergies. You can have chronic bowel problems as my nurse was mentioning a few minutes ago related to ingestants. And probably one of the biggest things with allergies is when people have all of this stuff going on, they often have fatigue, they often have a quality of life issue, they don't feel well and they're tired. I went back to my doctor and said, you know what, I think I have food allergies. She said, there's no such thing. I think the general perception is allergies are just some minor thing that, oh, if you complain about them, you're just kind of whiny and nerdy. We see so many people who are hopeless and when they come here, and they come from miles around, Montana, Florida, we have people that come from China every two years. So they're not coming because they have a little cough or a little post-nasal drainage. They're coming because they're very complex and nobody's figured it out. - It's 2008. I have had issues with allergies when they had the flood over here in Cedar Rapids. It was the first time I was tested, and I was very much allergic to mold and dust, and I would lose my voice. I mean, it was ridiculous. To where, you know, when you're having like a bronchial attack where you can't talk, you can't breath, you can't do anything. I thought I was just sick, and then they had my allergies tested. At the first place, they had two allergies, and I'm like, okay, well, I tried doing four Benadryl a day. Try working and driving; it didn't really work very well. I have a 10 year old that has the same type of allergies and we thought she had a cold most of the time because... Forever telling her to get a Kleenex. And after going through the test and we found out, wow, we live in Iowa, surrounded by corn fields, soy beans, wheat, trees, grass, the whole nine yards, and we're allergic to it. Allergies can really define you because it defines how you see the world and what's around you. But a lot of it, I don't remember because I was so little and I think I blocked out a lot of it, and I rely mostly on my mom to tell me what actually happened. The first time I knew Alex had allergies was when I had him in the high chair one day and I gave him a half a piece of toast with just a thin layer of creamy peanut butter on it, and I washed him break out in hives and I knew that it was the peanut butter because he had not had that before, and so luckily, it was treated quickly with Benadryl. I was able to treat it quickly with Benadryl, follow up with the pediatrician, had a discussion about this, and of course, we avoided peanuts, but from then on, I was on alert as to what other foods maybe he's sensitive to. I've always had the allergies. Nobody else in my family is allergic to really anything at the level that I am. - Alex is our fourth child, and so I was an experienced parent but I had never had a reaction like this with any of my kids. I had a few allergic reactions with peanuts when I would eat peanuts, and I would just like break out and it would be, my throat would swell up and I'd just down a bunch of Benadryl and that's pretty much all I've ever done is taken so much medication. When I started taking Alex to the allergist, he did a lot of the skin testing that was normal for environmental and yes, some of that did show up and we started allergy shots at the age of five. However, he really did not listen to me when I said, what about foods? Couldn't there be other foods if he's allergic to peanuts, then how do we test for that? And he really dismissed me and said, well, mom, we just can't test for everything. And you know, you can't take him off of all foods. So the treatment really didn't help. The shots didn't help; Alex just got progressively worse, and then he started having this muscle pain and cramping and that was causing problems at school, sitting in his desk and just being very uncomfortable, waking up with leg cramps, and that was terrifying. They sent me to elementary school in second grade and I have a little pad on the back of my metal chair and this pad was like this. I mean, it did absolutely nothing. It was the stupidest thing I've ever seen, but I had to sit with a pad and that identified me to all the other kids that there's like, Alex apparently has to have a pillow while he's at school and that makes you just look ridiculous. I think that it's easy to underestimate how much allergies can impact your life. They impacted Alex's social life. I think they impacted every aspect of his life because when he was little, he didn't feel well so much of the time, and that really impacted what he was able to do, what he felt like. You know, he tried flag football but he would be sliding in the grass and would come out with rashes all over so we stopped that. And that impacts all aspects of a child's life. When I would go outside and I'd see people sitting in the grass and to me, I'm like why would you wanna do that? Because for me, sitting in the grass makes me itch. So allergies change your entire perspective of what the world is around you. I look at grass as an enemy. People look at grass as something that's like fun to sit in and roll around and go outside and play, and I just think of it as, I'm gonna sit... Who sits down barefoot in the grass? He was going to the emergency room probably monthly and having horrible rashes and was on steroids, prednisone frequently; also had a nebulizer that we were doing treatments with daily. So a lot of meds and he was losing weight, he was just really starting to look sick. I remember I had a girl that thought I was sick and would tell me that all the time, and it's just like, geez, nobody had any understanding or sympathy and they just think that you're being really whiny, and that it's your fault that your allergic to stuff and that it's your fault that you can't do what other people can do and that wasn't my choice, and so now I think more people are beginning to understand that. One year, we spent $11,000 out of pocket just going around getting different opinions, and we had excellent insurance. I worked at a hospital where we had our insurance, but you know, it really adds up quickly and he saw rheumatologists; he also saw an immunologist. At age seven, he was diagnosed with fibromyalgia and I just really thought that was ridiculous. I never thought it was fibromyalgia. I just did not believe that, a seven year old. And then we took him to Mayo Clinic, and Mayo Clinic doctor looked at all of the testing that had already been done by the allergist who came to Fort Dodge; did not reside there but came to Fort Dodge, and just said, well, this looks pretty good and didn't retest any of it and he actually said to me, well, we'll just have to hope that it goes away and I was so angry and he knew it. Of course, that was from fear. I was terrified because I thought if Mayo Clinic doesn't know how to help my son, then where am I gonna go next? What are we gonna do? - What was strange is to me, it was just like this is my life. This is what it will be, this is what it will always be. I will always have to not eat what everybody else eats. I will always have to kind of live in a bubble. I'm pretty stubborn and so I decided to just keep looking. We were gonna look until we found something that worked and this was before the days of Google, so you really couldn't look for resources as easily as you can now, but I'd heard about a clinic Dallas, Texas and we were getting ready to take Alex there when another friend told me about Allergy Associates in La Crosse and said that they had had a lot of success there and this woman had even gone through gallbladder surgery that had been a misdiagnosis when in fact, it was a lot of different symptoms from allergies. When I found out that I had allergies, my original thought was great, I'm gonna be taking pills and having a nasal spray the rest of my life and I got lucky, I ran into the Allergy Associates of La Crosse as a reference from my sister and a person I worked with, and taking the time to drive four hours to the office to get checked out up there was the best decision I ever made. I always tell people that my mom gave me life twice. She gave me life when she actually had me as a child, and then she gave me life when she took me to Dr. Mary's office and solved what kept me from enjoying the world that she brought me into. - When I took Alex to La Crosse, I was surprised that it was small because I just imagined this great big clinic. It clearly was not like originally a clinic. We were in the professional arts building which is part of St. Francis and it was the old nursing dormitory that had been sort of put to clinical use by my dad, and as each doctor came, we got a little corner, a little more space. I actually started working in the clinic when I was 13. I worked Saturday mornings and summers from the time I was 13 until I finished college and went off to medical school, so I had had a long experience with the clinic. I saw the patients myself. I mean, not by myself but I was here. I heard them talking about the success they'd had and it was exciting to me to be able to actually make those types of changes. - I was a former engineer. I have a very pragmatic approach. You know, what are you doing and is it working? And when I came to Dr. Morris a few years out from my training, I was not happy with how I was doing with shock therapy at all, and Dr. Morris offered this approach and I thought, let me try it and I'll see if it's helpful. And as I said earlier, the rest is history. Allergies quite simply are a pathologic response to a normal thing in the environment. So for example, someone can be outside in the middle of August and say this is the most beautiful thing I've ever seen, and the person standing next to them is sneezing, itching, their immune system has become activated, they're inflamed everywhere, miserable, and the two people are in the exact same environment. Those are things that our body should tolerate and for some reason, our immune systems have decided that they're foreign and they are a danger to our bodies so our immune systems gonna activate it and start fighting. So let's take a look at what's happening inside your body visually when you have an allergy. Allergies are an overreaction from the immune system. The immune system is what fights off a disease or foreign substance. People who have allergies have an immune system that reacts to something in the world that's usually harmless, like pet hair or pollen. Any substance that causes an allergic reaction is called an allergen, and people can be allergic to a lot of stuff. A person can be exposed to an allergen by inhaling it, swallowing it or getting it on their skin. After a person is exposed, a series of events create what we think of as an allergic reaction. Number one, the body starts to produce a specific type of antibodies. Number two, the antibodies then attach to specific types of white blood cells and tissue cells. This causes these cells to release a variety of chemicals. Histamine, the main chemical released, causes most of the symptoms of what you think of as an allergic reaction. This is why a lot of over-the-counter medication is called an antihistamine. It prevents the body's natural reaction to foreign substances by preventing or blocking histamines. It's somewhere between 50 and 70 million Americans that have allergies of some sort, and then you pile on top of that the people that have asthma, most of that's caused by allergy. Sinusitis, it's usually some kind of a mold sensitivity in the sinuses. And you layer on those numbers, it's a huge, huge number of people that would benefit from addressing the cause of their allergies. I was like one of one or two kids who was allergic to peanuts and had all these allergies, and now it's totally different. Think of it as a growing issue. It may be a littleoverstated on how much it's grown. I mean, I think it's grown significantly in the last probably 50 years. I'm not sure it's been just 10 years. I think a lot of this has to do with survey and awareness and the way we're looking at it. Eight, seven, six, five, four, three, two, one. Alright, let's start walking, good job, guys. Thousands of people every year are newly diagnosed and we're just trying to raise some funds to give support to our community and letting people really understand what a food allergy means. It's not just that you have to avoid the food. If you don't avoid the food, you could die. I can tell you that the incidence of food allergies in young children has grown exponentially since I've been in practice. When I think back to just the rare child that I had with life-threatening food allergies to now, every single day, I'm seeing children with not just one food allergy, but several. What usually surprises people is that allergies are a disease that mainly affects the developed countries, the economically powerful western countries that are cleaner, we have a different food system than other countries. It's those, it's the powerhouses that end up suffering from allergies the most. My own feeling is over the last three and a half decades or so that I've seen more people with food sensitivities than I used to, and none of us as allergists are absolutely sure why that is. I don't remember anyone when I was growing up having food allergies, and now, for example, in my son's class, there's him and another girl. We probably have 20 other people at the same school that have a food allergy, so it's just much more common than I remember it ever being when I was growing up. There are several research studies that they are funding that both deal with trying to find a cure and also until a cure is found, dealing with treating symptoms and things that we have now that we know we're living with now, so yeah, they're working on both fronts. - There are a number of factors. A big one is cigarette smoking. Then you go into other areas like climate change. Well, when it comes to the CO2 levels, we know that weeds love and thrive on higher CO2 environments. Our immune system is losing its direction. This is just to put it in a nutshell. Longer pollen seasons, sedentary lifestyle, obesity. Diesel particulates have been shown to increase the incidence of asthma. And in certain areas, we're getting a lot more moisture. So in general, those kind of things have a factor. There is some discussion about what's going on with changes that we've made in our food supply. We certainly see patients here that are sensitive to food additives, dyes, things like that. We know that processing of food has altered it to some degree, and for sensitive individuals, they're having problems with that. Probably the most common thing you'll hear about is one called a hygiene theory, where our western lifestyle predisposes individuals to develop allergy or asthma, and that's kind of a good and a bad situation 'cause if you're aware that around the turn of the century, last century, we had a 50% infant mortality rate from a lot of the bad things like poor hygiene, poor food handling, you know, things like that. And the fact that we've improved those public health measures, that's what really the westernized lifestyle is all about. So you've taken out off the table kids dying from measles and strep and things like that and so now they don't have that immune response going on. They may be more predisposed to develop the allergy immune response. One of our concerns, of course, is the issue of the altered microbial environment in the intestine and with the advent of antibiotics and the frequent use, I think that that can potentially amplify the development of food sensitivities. There's this one study from the University of Chicago that shows a link between using antibacterial soap and medicine when you're little to children who get allergies. What their theory is that because you're getting rid of all of the germs when you're little, you're also getting rid of the good bacteria, so it means that you can also get allergic to things that are not actually bad because you're cleaning it all off and your body's not gonna be used to it when it comes into contact with it in normal life. So we may be using too much medication when we're little or washing our hands too often. Sometimes, children or young adults will have an allergy condition that manifests principally with recurring infections, and this may be chronic throat infections, chronic ear infections, and by necessity, the children are given antibiotics to use. Now, like anything else, if it's once in a infrequent interval, it's probably not a big thing, but it's not uncommon for us to see children in here who have been on five, eight, 10 courses of antibiotics in a year. Now it would make sense that their intestinal flora has been altered under those conditions, and we know that proper intestinal flora helps to maintain immunologic balance. So one of our concerns as a profession is we may be needing to intervene at an early stage. Typical treatment would be avoidance, trying to stay away from those things that you're allergic to and/or pharmacotherapy, taking medications. And again, if you do the latter two, you're just addressing the symptoms and you're really doing nothing about the cause. So not having something to change the course of the disease, I think people just said, you know what, we'll live with it. We'll put up with it; it's really the prevailing approach. But it's not really what is going to ultimately make a difference in somebody's lives. We take small amounts of what a person's allergic to and introduce them gradually into the body Traditionally, subcutaneous immunotherapy, allergy shots have been the mainstay, and they still are the most effective overall for most patients. I don't like shots, I don't like needles. I don't even take a flu shot with a needle. I have to do the inhalable. The exciting thing about what we do, which is different than allergy shots, is we actually put the extracts under the tongue. I've had allergy shots, and I think my mom said I did it for one or two years and it didn't make a difference, and I'm not really sure why the drops work sometimes for people when it's under their tongue and not in the arm, because it's the exact same allergy extract. It's the same stuff. It's just a different way of going into your body. How it works is you take a drop under your tongue three separate times a day. You get a bottle for your environmental allergies and then you get a bottle for your food allergies, and inside each one drop is all the antigens that you're allergic to, so with one drop, you're fighting a bunch of different allergies, and the idea is that it just builds up resistance against those allergies 'cause it exposes it little by little to your body and then your body says, alright, this isn't so bad. I think I could get used to this. So everything we're talking about, like with sublingual immunotherapy, the drops, that's an off-label usage, so the extract is available. So the physician feels based on the current medical evidence and the literature comfortable in doing that, they're able to use it that way. Because it's not FDA approved doesn't mean we can't use it. It just means that none of the insurance companies, Medicare, Medicaid, will cover the sublingual drops, so that's a challenge for patients and they have to pay out of pocket. In the 60's, when my dad started doing this, no one understood how that could possibly work, but we now realize that that is a very privileged immunologic site in the body. Dr. David Morris's health didn't allow him to be interviewed by us, but he got started by treating Wisconsin farmers for their mold allergies. He tried shots but they just didn't work. So he didn't come up with the idea of drops and he's not the only doctor to use it. The first known use of these drops was used to fight a dust allergy back in 1900. By 1936, Dr. French Hansel became the first guy to publish anything that showed these things can help get rid of dust allergies. Like we said, Dr. David Morris didn't even find out about allergy drops until the mid 1960's, when he goes to an allergy doctor's conference in Hawaii. Then he gets to writing himself, and publishes his own paper on how he thinks drops can even help stop food allergies. In 1970, he opens his clinic in La Crosse, Wisconsin. It takes a long time for the process to be taken seriously, but by 1998, the World Health Organization says sublingual immunotherapy, or drops, works just as well as shots. He was presenting at, I believe, at our State Allergy Society meeting and one of the doctors stood up and said, okay, well, he started talking right in the middle of his giving the lecture and goes, well, how could that work to his colleagues. That's ridiculous, they don't. It was very, very difficult. I would say I felt shunned that it was at least perceived by me, that if I would sit down, people would get up and leave, or if I'd try to talk to someone, they would turn from me and walk away. Allergy Associates of La Crosse was treated like they didn't even exist. When I had joined Dr. Morris years ago, it was pretty much an ignored area. So at medical meetings, for example, we were put the farthest table away from everyone else. We would talk about what we do and people would just roll their eyes. You know, the support, the enthusiasm behind sublingual hasn't really developed with the college or the academy. Our partners, they all knew we were goodhearted, very solid basic physicians, but they seemed to think we had a little quirk. I don't really know specifically what they do and what they don't do as far as the type of treatment they use. I think it's unfortunate they felt that way that they were being shunned. I've never intentionally shunned anyone if they're, you know, at a meeting or something. Well, the response is getting better. I would call it the movement glacial. It's moving, and it's gonna continue to move. There was also a period of time where there were many meetings that we went to, the college and academy meetings where there was just outright discussion about the impact of sublingual on the income of the allergists. When you're delivering the shots, you have this steady, recurring, you know, weekly, biweekly, monthly, you know, for years on end of patients coming in and getting their shots, which provided an ongoing revenue stream, so yeah, there's a lot of discussion around revenue. Well, heck, it's great. We'll just put it in under the needle and then we get paid every time you come in for an office visit. We get paid every time you get a shot. You know, over and over again, and the bottom line comes down to it's a lot cheaper to do under my tongue every day, myself, than it is for me to take off time from work to go down, pay the doctor, pay the office visit, pay the shot, to get the same result. So your question is, I'm gonna repeat it, would an allergist make a decision solely on financial reasons as far as choosing subcutaneous or allergy shots over other treatments. The answer is I would hope not. I think that, I can't speak for every individual allergist. There are around 5,000 board certified allergists in the US, and when we look at treating the patient, we look at multiple factors, and certainly, it would be very unfortunate if an allergist chose a therapy just because they thought there was a financial incentive. I think that'd be no different from an oncologist treating a cancer patient because they administer the chemotherapy in their office, which a lot of them do. And I think there is always in any business or any field, you can, including the media, there may be people that do things because there's a financial incentive. You can't ever eliminate that human behavior, but I would say that the vast majority, 99% of physicians, try to offer their patients the best treatment based on their current medical scientific knowledge. Allergists who's in the community takes a considerable risk to stop his or her practice with injection immunotherapy and begin sublingual immunotherapy if it isn't covered by insurance. So you have each side not wanting to take the first step, because of their own issues, both being in a sense, somewhat financial. Sublingual immunotherapy has never really been gone through some of the rigorous studies. There are more studies being done. The US government looked into which works better, drops or shots. And, like pretty much everything that the government does, they say, okay, we need to continue to study this. What's important is they found almost the same level of effectiveness for both of them. They couldn't decide. What's really important here is that they couldn't say that drops doesn't work and that shots work. They say, well, they both seem to work. Over the years, the sublingual immunotherapy, some of the problems have been in the scientific studies, you couldn't see the biological markers as we knew more about what immunotherapy did, but I think as we move into another era, you're gonna see that some of that will be validated. Oftentimes, an insurance company's not gonna cover the allergy drops, and one of the big reasons for that, probably the biggest reason for that, is because a lot of insurance companies base what they reimburse on Medicare rules, and back in the 1990's, Medicare ruled that drops are not safe and they're not effective. - We have shared our protocol. You know, we have an extensive 130 page protocol that explains where it came from, how the mechanism works, everything, with the FDA, with the leaders, with the presidents of the college and academy and whatnot, and yeah, all of that information that we've provided has really gone without really being looked at, at least to our knowledge, and we're not quite sure why but there's been research studies that have been started and whatnot and the invitations that we've had to be involved in those have been few and far between, but we've initiated a lot of our own research to do that. Now, there's so much scientific evidence that shows this works. The older doctors seem to be hesitant to make any changes in how they do things, but I'm seeing a real change in the younger doctors. They're still at a stage in their lives where they can look for themselves and say, oh, well, indeed this is safe and effective. Why aren't we doing this? So I think part of it is we have to just hope the older people are not in positions of power. So we did a Freedom Of Information request to find out what is the basis that the FDA has allowed allergy shots. We wanna know how do they know that they work, why are they FDA approved and drops aren't, and what we ended up finding is it's called the Summary Basis of Approval, or why they approved it in the first place. I did this for all five major pharmaceutical companies that have allergy extracts, and all the Summary Basis of Approvals said the same thing. Because there are no adequate, well-controlled trials with this product to prove efficacy, efficacy means does it work, the optimal treatment must be based on the clinical response of each patient. So, what they're saying is it's based on patient to patient. None of them have had to do the types of studies that the FDA now demands of drops. We then turned to the FDA and asked, okay, why did you approve something that there was no well-controlled study to approve? And their response made total sense. Allergy shots were proved back in the 1920's, and you didn't actually have to prove how well any of your products worked to the federal government until 1962, and after that got passed, the FDA has since been trying to make the shots meet their current standards and they've done study after study in the 80's, some shots are not available anymore, but you can actually still watch the advisory committee hearings where all these allergists get together and talk about whether or not the FDA should approve stuff, and they're seeing that the shots don't meet the current standards but they know the shots work. Once these are taken off the market, the road back is very difficult. It's not gonna be the same standards, and I think once our extract is removed from the market, it will be years, likely, before we have that available again and I think there's a real possibility of taking a step backward in terms of our clinical care that we can offer to patients and to the public. And it's just like, you know, drops work but they aren't even in the discussion really for FDA approval, and you can hear them talk about how they don't wanna get rid of these shots because they know these extracts work, but they also know that they don't meet the current FDA standards, so there's a lot of nuances here. You can actually even hear one guy ask, so, since sublingual drops are the same thing as shots, can companies also just get grandfathered in and we can start using that? Quite a few clinical studies now evaluating rules for certain various aspects of sublingual and oral therapy. As one of these studies actually verifies an extract as showing efficacy. I hate to simplify it, but essentially, what they say is they have to start from the ground up and do these well-controlled studies and meet the standards since it's a different way of taking the treatment. I don't know what the FDA approves or doesn't approve. I do know that this is the same stuff that they approved for giving it to me in the arm, so I don't see why they can't say sublingual is just another alternative way of delivering the same product. For our investigation, we asked three of the pharmaceutical companies that make extracts, if they ever wanted to get approval for their stuff to be used as drops. You know, did they ever try and it just failed? We wanted to know, and Allergies Laboratory, Inc. said they have never pursued it. Greer said they are planning to do it, and ALK totally ignored the question and responded by telling us about their brand new pill that you can put under your tongue if you're allergic to grass or ragweed. - This was recently approved through the FDA in this country. It's been approved in Europe for about 10 years. These sublingual tablets, they're actually a form of immunotherapy, right now approved for only grass and ragweed in this country, and they've been show to be effective for those two if you have patients who are only sensitized to those two so that's kind of our treatment options we have. The most important development has been the release of the grass and ragweed tablets that treat a single allergen, allergy, if you will, and that has really kind of awakened the notion and interest in sublingual, even more than was there before. For my patients as a whole, it really doesn't matter because we do what the grass tablet is doing. We give virtually the same dose and we do it on a regular basis as part of our treatment. - It still doesn't address the multi-antigen approach, the multiple allergies that people have and addressing all of those simultaneously which is what we do in the La Crosse method protocol. Sublingual therapy is versatile. You can give a dose to suit the patient's own allergy condition. Each immunotherapy set that the person receives is customized for them, so unlike some of the newer single antigen tablets, for example, that are, quote, one size fits all, end quote, with this form of immunotherapy and the way we do it here, various things are escalated at varying rates depending on the clinical response. So for example, I personally see that dust mite, pollens, cat, dog, tend to improve more quickly than something like mold allergy. - What we're pleased about is so here's some FDA approved products saying that sublingual works. It's safe, it's effective and so it's a step in the right direction and we're glad of that. What's important here for my life is that shots and pills only deal with environmental allergies. What Allergy Associates does also helps you fight food allergies. When we left there that day, we had a lot of answers. I knew that he was allergic to corn and all corn products, corn starch, corn syrup, yeast, grapes, which I had just sent in his lunchbox the day before, and I'd not known that, but then I knew why I couldn't figure out what foods he's allergic to because corn starch and corn syrup and yeast are just in everything. So by getting him off of those foods, we started immediately to see an improvement. Then the magnesium level was low, and that is what she concluded was causing the muscle cramping, and she said, you know, it's hard to know for sure but we think that the allergies are acting as a major illness in his body and depleting his body of magnesium. So she put him on a supplement. My thought, that if the heart's a muscle, you know, what effect could this have taken over years? Maybe even his life, if this had not been diagnosed properly. I remember I was allergic to yeast and I had to eat this fake bread, and it's like, what even is bread if it's not yeast? I don't even know what I was eating. And now I can eat a sandwich. I can eat anything I want, almost, except peanut butter. My peanut allergy is so bad that they haven't been able to get that totally under control, but they have been able to do it for a lot of other people. In addition to getting him off the foods that he was allergic to and the magnesium supplements, they started him on the allergy drops, and that was wonderful relief to me because I could give them at home. It wasn't another doctor's appointment and time off work for me, time from school for him usually, and pain, of course. - It's changed my entire world. I'm able to have confidence. People don't know I have allergies unless I tell them. That's a huge difference. Everybody could tell immediately when I walked into a room that I had allergies or I had flu all the time, one of the two things. And that's all gone, so I can actually... I'm now part of society. ER visits were really eliminated. He wasn't on prednisone anymore, so the cost of medications also went down. Dr. Mary, though, she's my angel because I really feel like she saved Alex's life and the drops have been a wonderful form of treatment. He is a whole different person. In fact, last year, he ran the Chicago Marathon and both my husband and I were just in tears because we never, ever would have thought that this little boy who had this horrible breathing issue and asthma and eczema, we didn't think that he would ever be able to do something like that. I can sit in the grass with my shoes off and it's gonna cause a massive reaction. I can pet a cat, I can pet a dog. I can eat corn, I can eat my popcorn now. I went right back to the allergist we had dealt with for two and a half, well, more than that, two and a half years earlier, and pretty much went head to head with him. I just wanted him to know exactly what we'd done. He looked at the documentation, called it rubbish, and I said, well, you know what we've been doing for several years now has not been helping. Alex is visibly getting worse, and so we're gonna try this because this makes sense to me, and he was very angry, but at that point, I didn't care. I was gonna try it and I felt like we were on the right path and then this last year, which has been 18 years later, one of my friends told me that a man told her that he was taking his son to La Crosse because that same allergist referred him there, and I asked her to repeat the story because I thought I must have heard it wrong, and she said, no, he actually referred someone to La Crosse, to Allergy and Associates, and I said, well, then Hell just froze over. I can't believe it. The difference now is my eyes don't water. I can breathe and I can be outside 24/7. I can go camping again. I can do anything, and this doesn't stop me at all now, where before, it was miserable. Before, it was like, oh, get Benadryl. I'm sorry, Benadryl makes me go to sleep. They had me on four Benadryl a day, trying to cover it up, where now, it's like, stop, take a squirt. Twenty seconds, I'm out the door. I mean, it's a no-brainer, it's a game changer in my world. There's certainly many allergists that have practice using sublingual immunotherapy and why that hasn't become more mainstream, you know, that's a question I think only the leadership of the college, the ACAAI and the Quad AI can answer. Sublingual immunotherapy will be accepted. It's not a question of if it's gonna become the dominant treatment. It's just a question of when. Patients will drive it, they'll demand it, and I think that's the other reason you're seeing some of the work and acceptance in the American allergy community is that they have had two things happen. They've had their European colleagues emphasize the effectiveness of the treatment, colleague to colleague, and you've had patients come up and demand it because they have seen its benefits in relatives and other people. There has been a huge change, I would say, in the last five years, especially now that the science is solidly behind it, so suddenly, I'm having people come up to me at meetings and going, wow, you guys were right. So all of that's been kinda fun. You should be allowed the option of using drops. It's not about getting rid of shots and taking this away from allergists as a great tool. It's just, let people do it at home, let people try it. If you say we can't let people do it because they're not gonna be responsible enough to do it, well, that's stupid. You need to let people be adults. And if there's better ways to do things, or at least comparable ways to do things but more people will do it because compliance and adherence and that'll be better, we need to pursue those things. If we're gonna make any kind of a dent in the health care costs in this country and improve health overall and all those sorts of things, that's what we have to do. We have to be pursuing those things. So I think the rationale, what is driving health care and health care change today is different than it was. We cannot put up with the status quo. It just isn't getting the job done anymore, and there's so much innovation out there that we do need to find, harness it, focus it in the right direction. It's gonna have a huge impact on costs, health care costs and also the overall health of the country. We're dealing with the immune system. As we all know, it's highly complex. So as we learn more, the more we learn, the less we know, and I think we'll have a lot of treatment options in the near future and down the road, the next 20, 30 years. Certainly, a young physician starting out in this field now, when they reach the stage after 35 years like me, there's gonna be a lot of breakthroughs, I think. - Was there anybody in history that my dad really identified with? There's a Dr. Semmelweis that my dad always would bring up. He spent his entire career trying to get doctors to wash their hands, not only after autopsies, but in between patients and he was so ostracized by the medical community because of that, he ended up dying in an insane asylum. It was something that now we look back 150 years ago and say, how could that possibly be? That the doctors were so insulted and felt that they were being accused of killing these women that they couldn't take a step back and say, okay, what could we do differently? Which is wash your hands. So that's the story my dad always brings up, is, you know, 150 years from now, we'll probably look back and go, well, that was such a common sense thing. How could that have caused a controversy in the medical community? |
|