- Desperate (1947)
- Desperate Hours (1990)
- Desperate Hours, The (1955)
- Desperate Journey (1942)
- Desperate Living (1977)
- Desperate Measures (1998)
- Desperate Trail, The (1995)
- Desperately Seeking Santa (2011)
- Desperately Seeking Susan (1985)
- Desperation (2006)
- Despicable Me (2010)
- Despicable Me 2 (2013)
- Despicable Me 3 (2017)
- Despite the Falling Snow (2016)
- Destination Anywhere (1997)
- Destination Moon (1950)
- Destination Titan (2011)